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PT-141, a synthetic peptide analogue of alpha-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system. Administration of PT-141 to rats and nonhuman primates results in penile erections. Systemic administration of PT-141 to rats activates neurons in the hypothalamus as shown by an increase in c-Fos immunoreactivity.1
|Product Name||Bremelanotide (PT-141)|
Molinoff, P B, et al. “PT-141: a Melanocortin Agonist for the Treatment of Sexual Dysfunction.” Annals of the New York Academy of Sciences, U.S. National Library of Medicine, June 2003, www.ncbi.nlm.nih.gov/pubmed/12851303.
“What Is PT-141?” What Is PT-141 – Creative Peptides, 27 Apr. 2017, www.creative-peptides.com/article/what-is-pt-141-10.html.