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Melanotan II is a synthetic analogue of the α-melanocyte stimulating hormone (α-MSH). α-MSH is a melanocortin I receptor agonist which has a role in human pigmentation by stimulating production of eumelanin. Melanotan II was originally developed as a treatment for sexual dysfunction. However, the proposal was abandoned when development of the metabolite bremelanotide was established.
Melanotan 2 is a small efficient molecule as compared to the linear original Melanotan I design after natural melanocyte stimulating hormone peptide. Melanotan is approximately 1,000 times more potent than natural a-MSH. Melanotan half life of minutes, Melanotan 2 half life ~1 hour.
Melanotan has shown to accelerate tanning, increase libido and suppress appetite. Synthetic melanocortin therapy helps attain a tan with the least amount of exposure to harmful ultraviolet radiation.
|Molecular Weight:||1024.198 g/mol|
Australian Government Department of Health. “1.7. Melanotan II.” Therapeutic Goods Administration (TGA), Australian Government Department of Health, 5 Feb. 2018, www.tga.gov.au/book-page/17-melanotan-ii.
“Melanotan II.” National Center for Biotechnology Information. PubChem Compound Database, U.S. National Library of Medicine, pubchem.ncbi.nlm.nih.gov/compound/Melanotan-II#section=2D-Structure.